Screw him, you, that, etc.
Definition 1 of 3

Expressing Frustration
It's used when frustrated with situations or outcomes, not necessarily directed at a person.

Screw it, I'm going home!
Strong Dismissal
Shows strong rejection or dismissive attitude towards something considered unworthy of consideration.

Screw that noise, I'll do it my way.
Informality
Highly casual and informal; could be inappropriate in formal or unknown company.

Screw the rules, this is more fun.
WordUp Chrome Extension
As you browse the web instantly look up words you don’t know.
Get Chrome Extension
