Be out of your mind with worry, etc.
Definition 1 of 1

Emphasis on Extreme
The phrase implies an intense level of emotion, more than just being worried.

When the hurricane struck, they were out of their minds with worry for their relatives.
Not Literal
It's a figurative expression meaning someone is very worried, not physically out of their mind.

He was out of his mind with anxiety over the lost documents.
Crisis Situations
Often used during situations of danger or high stress to describe someone's state of mind.

She was out of her mind with fear when she heard the sirens.
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